| P
C PÊÊ (Phencyclidine)Ê
In
the 1950s, phencyclidine was investigated as an anesthetic
but, due to the side efffects of confusion and delirium,
its development for human use was discontinued.Ê
It became commercially available for use as a veterinary
anesthetic in the 1960s under the trade name of Sernylan
and was placed in Schedule III of the CSA. In 1978,
due to considerable abuse of phencyclidine, it was transferred
to Schedule II of the CSA and manufacturing of Sernylan
was discontinued. Today, virtually all of the phencyclidine
encountered on the illicit market in the United States
is produced in clandestine laboratories.
Phencyclidine, more commonly known as PCP,Ê is
illicitly marketed under a number of other names including
Angel Dust, Supergrass, Killer Weed, Embalming Fluid,
and Rocket Fuel, reflecting the range of its bizarre
and volatile effects. In its pure form, it is a white
crystalline powder that readily dissolves in water.
However, most PCP on the illicit market contains a number
of contaminates as a result of makeshift manufacturing,
causing the color to range from tan to brown, and the
consistency from powder to a gummy mass. Although sold
in tablets and capsules as well as in powder and liquid
form, it is commonly applied to a leafy material, such
as parsley, mint, oregano or marijuana, and smoked.
The drug's effects are as varied as its appearance.
A moderate amount of PCP often causes the user to feel
detached, distant and estranged from his surroundings.
Numbness, slurred speech and loss of coordination may
be accompanied by a sense of strength and invulnerability.
A blank stare, rapid and involuntary eye movements,
and an exaggerated gait are among the more observable
effects. Auditory hallucinations, image distortion,
severe mood disorders, and amnesia may also occur. In
some users, PCP may cause acute anxiety and a feeling
of impending doom, in others, paranoia and violent hostility,
and in some it may produce a psychoses indistinguishable
from schizophrenia. PCP use is associated with a number
of risks and many believe it to be one of the most dangerous
drugs of abuse.
Modification of the manufacturing process may yield
chemically related ananogues capable of producing psychic
effects similar to PCP. Four of these substances (N-ethyl-l-phenylcyclohexylamine
or PCE, l- (phenylcyclohexyl)-pyrrolidine or PCPy, l[l-(2-thienyl)-cyclohexyl]-piperdine
or TCP, and l-[l-(2-thienyl) cyclohexyl] cyclohexyl]
pyrrolidine or TCPy have been encountered on the illicit
market and have been placed in Schedule I of the CSA.ÊÊ
LSD is also a Schedule I hallucinogen
| PCP |
| Effects |
| Like cocaine, PCP produces a profound
sympathomimetic state with both dopamine and norepinephrine
effects. Users, report excitement, euphoria & often
a mild hallucinatory state. Older docs can compare
it to "Ketamine," the 1967 drug for I.M. anesthesia.
Ketamine had short popularity because, like PCP,
it was unpredictable and caused wierd post-use phenomena
-- including psychosis. |
| Incidence
of Abuse |
| Use tends to be "regional." (Mostly D.C. & San
Fran/San Jose Area) Most places, PCP use is quite
rare!... But it is definitely spreading! |
| Chemical
Name |
| Phencyclidine, "PCP." PCP is chemically very similar
to "Ketamine". |
| Forms
and Street Names |
Angel dust, Hog, Peace Pill, Water
Ketamine (still available as veternary anesthetic)
has nickname "Special K." Ketamine abuse is probably
much more widespread than PCP abuse. |
| Preferred
routes of administration |
| Most often smoked -- often with Marijuana. Also
used I.V., sub-q, and nasally (snorted.) |
| Length
of time detectable after user |
2 - 4 days. Elimination is pH dependent.
ACIDIC URINE ENHANCES EXCRETION!
CAUTION:
- Acidification will "backfire" on donor because
it increases urinary concentration!
- Do not acidify urine during intoxication because
this can exacerbate myoglobinuric renal failure
secondary to rhabdomyolysis!
[EMERGENCY MEDICINE, JULY 1995]
|
| Metabolite
Actually sought in urine |
| 10% of parent PCP is excreted unchanged. The remainder
is hydroxylate or glucuronide. Screening and gc/ms
are sensitive to PCP and metabolites! |
| Confounding
drugs (or factors): |
| None known! |
| Screening
Cut-off: |
| 25 ng/ml |
| Confirmation
GC/MS Cut-off: |
| 25 ng/ml |
| Facts
for Verifying M.R.O |
| The claim of medicinal or innocent use is spurious!
There is NO LEGITIMATE USE! |
|